THE RELATIONSHIP BETWEEN HIF-2 AND CHRONIC RENAL ALLOGRAFT NEPHROPATHY IN RENAL TRANSPLANTATION RECIPIENTS

KOYUNCU S., UYSAL C., AKGÜN H., KARAKÜKCÜ Ç., ERTÜRK ZARARSIZ G., KOÇYİĞİT İ., ...Daha Fazla

Annals of Medical Research, cilt.29, sa.7, ss.664-667, 2022 (Hakemli Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5455/annalsmedres.2021.11.607
  • Dergi Adı: Annals of Medical Research
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.664-667
  • Erciyes Üniversitesi Adresli: Evet

Özet

Aim: We aim to examine the role of HIF-2α on chronic allograft nephropathy (CAN), which is a consequence of chronic inflammation and fibrosis in patients with renal transplantation. Materials and Methods: The study was conducted between November 2019 and January 2021, patients who had a renal biopsy in our university in the last two years were enrolled in this study. Fifteen recipients with a diagnosis of chronic allograft nephropathy proven by biopsy, 15 recipients with an eGFR below 60 ml/dk for other reasons as non-CAN group. Also, fifteen patients with an eGFR above 60 ml/dk were enrolled in the study as a control group. Serum HIF-2α levels were analyzed by the immunoassay technique. Results: HIF-2α was found higher in the CAN group compared to other groups. HIF-2α was significantly predictive in ROC analysis in identifying renal transplantation patients with CAN. The sensitivity and specificity of HIF-2α were 100% and 76% (cut off >0.2) with an area of under the ROC curve of 0.941 (95% CI 0. 850-1.000), p < 0.001). Conclusion: Serum HIF-2α may be useful both as potential biomarkers for diagnosing CAN after kidney transplantation and may be a guide in determining treatment strategies.