THE RELATIONSHIP BETWEEN HIF-2 AND CHRONIC RENAL ALLOGRAFT NEPHROPATHY IN RENAL TRANSPLANTATION RECIPIENTS
Annals of Medical Research, cilt.29, sa.7, ss.664-667, 2022 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 7
- Basım Tarihi: 2022
- Doi Numarası: 10.5455/annalsmedres.2021.11.607
- Dergi Adı: Annals of Medical Research
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.664-667
- Erciyes Üniversitesi Adresli: Evet
Özet
Aim: We aim to examine the role of HIF-2α on chronic allograft nephropathy (CAN),
which is a consequence of chronic inflammation and fibrosis in patients with renal transplantation.
Materials and Methods: The study was conducted between November 2019 and January 2021, patients who had a renal biopsy in our university in the last two years were
enrolled in this study. Fifteen recipients with a diagnosis of chronic allograft nephropathy proven by biopsy, 15 recipients with an eGFR below 60 ml/dk for other reasons as
non-CAN group. Also, fifteen patients with an eGFR above 60 ml/dk were enrolled in
the study as a control group. Serum HIF-2α levels were analyzed by the immunoassay
technique.
Results: HIF-2α was found higher in the CAN group compared to other groups. HIF-2α
was significantly predictive in ROC analysis in identifying renal transplantation patients
with CAN. The sensitivity and specificity of HIF-2α were 100% and 76% (cut off >0.2)
with an area of under the ROC curve of 0.941 (95% CI 0. 850-1.000), p < 0.001).
Conclusion: Serum HIF-2α may be useful both as potential biomarkers for diagnosing
CAN after kidney transplantation and may be a guide in determining treatment strategies.