A comparison between low-dose (1 mu g), standard-dose (250 mu g) ACTH stimulation tests and insulin tolerance test in the evaluation of hypothalamo-pituitary-adrenal axis in primary fibromyalgia syndrome

Kirnap M., Çolak R., Eser C., Ozsoy O., Tutus A., Kelestimur F.

CLINICAL ENDOCRINOLOGY, vol.55, no.4, pp.455-459, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2001
  • Doi Number: 10.1046/j.1365-2265.2001.01373.x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.455-459
  • Erciyes University Affiliated: Yes


Objective: Primary fibromyalgia syndrome (PFS) is a nonarticular rheumatological syndrome characterized by disturbances in the hypothalamo-pituitary-adrenal (HPA) axis. The site of the defect in the HPA axis is a matter of debate. Our aim was to evaluate the HPA axis by the insulin-tolerance test (ITT), standard dose (250 mug) ACTH test (SDT) and low dose (1 mug) ACTH test (LDT) in patients with PFS.