Rational design of EDTA-incorporated nanoflowers as novel and effective endodontic disinfection against biofilms

Aslan T., Dadi Ş., Kafdag O., Temur N., Ildiz N., Ocsoy I., ...Daha Fazla

ODONTOLOGY, cilt.112, sa.2, ss.444-452, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 112 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s10266-023-00857-2
  • Dergi Adı: ODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Sayfa Sayıları: ss.444-452
  • Anahtar Kelimeler: Biofilms, Catalytic activity, EDTA nanoflowers, Endodontic disinfection
  • Erciyes Üniversitesi Adresli: Evet

Özet

The ethylenediaminetetradiacetic acid (EDTA) is one of the most commonly used irrigation solutions. Although EDTA has a very low antimicrobial property, it is used to remove inorganic part of smear layer in areas of root canal system. Herein, we developed EDTA-incorporated nanoflowers (EDTA NFs), for the first time, as novel and effective irrigation solution with quite high antimicrobial property to provide complete disinfection in root canal system. We both systematically elucidated the formation of the EDTA NFs with various techniques, and their catalytic and antimicrobial activities in the presence of hydrogen peroxide (H2O2) were documented through intrinsic EDTA property and peroxidase-like activities.