SYNTHESIS AND CHARACTERIZATION OF NINHYDRINE AND AMINOGUANIDINE DERIVATIVES
9th International Uludağ Scientific Research Congress, Bursa, Turkey, 23 May 2026, (Summary Text)
- Publication Type: Conference Paper / Summary Text
- City: Bursa
- Country: Turkey
- Open Archive Collection: AVESIS Open Access Collection
- Erciyes University Affiliated: Yes
Abstract
ABSTRACT
Imidazole compounds are heterocyclic compounds with two nitrogen atoms and have broad pharmaceutical effects in biological systems due to their electron-rich nature [1]. The imidazole pharmacophore group, found in the structures of biological molecules such as histamine, DNA and hemoglobin, is important in pharmaceutical chemistry due to its weak interactions with enzymes and receptors. Ninhydrin (2,2-dihydroxyindane-1,3-dione) is a chemical compound used in synthetic organic chemistry for the synthesis of heterocyclic molecules that exhibit biological activity due to their structure and reactivity [2]. Guanilhydrazones (aminoguanidine) have been reported in the literature for the synthesis of different heterocyclic compounds due to their antibacterial, antimalarial, antisecretory, antidiarrheal, antihypertensive, antileukemic, antiviral, and anticancer activities [3]. In this study, novel 2-amino-3-(benzylideneamino)indeno[1,2-d]imidazole-8(3H)-one derivatives containing hydrazone groups were synthesized via the reaction of guanylhydrazone derivatives with ninhydrin and malononitrile. The synthesized hydrazone- and aminoguanidine-containing ninhydrin-based imidazole derivatives are anticipated to exhibit versatile biological activities. The characterization of the synthesized compounds was elucidated by 1H-NMR, 13C-NMR, FT-IR and HR-MS spectroscopic methods.