Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.36, sa.4, ss.230-237, 2008 (Scopus)
Aim: The aim of this study is to investigate the effects of 6 L min -1 and 3 L min-1 fresh gase flow during the sevoflurane anesthesia on the anesthesia cost, renal and hepatic functions. Materials and Methods: This study was performed on 90 patients, aged between 18-50 years, scheduled for elective surgery. Semi-closed respiration system was used for anesthesia. Patients were randomized into two groups. In both groups for first 5 minutes, anesthesia was maintained with % 1-2 sevoflurane in 6 L min -1 (2 L min-1 O2 + 4 L min-1 N 2O) of fresh gas flow and after then, anesthesia was maintained with % 1-2 sevoflurane concantration in 3 L min-1 of fresh gas flow (1 L min-1 O2 + 2 L min-1 N2O) in Group I ( n=45) and 6 L min-1 of fresh gas flow (2 L min-1 O 2 + 4 L min-1 N2O) in group II ( n=45). Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), end-tidal carbondioxide (ETCO2) and end-tidal sevoflurane (ETsevo) were recorded during the operation at 15 minute intervals. Arterial blood samples were taken for arterial blood gas analysis and venous blood samples were taken for blood urea nitrogen (BUN), creatinine, aspartate amino transferase (AST), alanine amino transferase (ALT), gama glutamyl transferase (GGT) and total bilirubine levels. Sevoflurane consumptions for all patients were recorded. Results: There were no statistical difference in HR, SAP, DAP, SpO2, EtCO2, Etsevo, SaO2, PaO2, PaCO2, pH and serum AST, ALT, GGT, total bilirubine, BUN and blood creatinine levels between the groups (p>0.05). Sevoflurane consumption was statisticaly higher in group II than in group I (p<0.05). Conclusion: By using semi-closed anesthesia system with decreased fresh gase flow from 6 L min-1 to 3 L min-1, sevoflurane consumption was 51 % decreased without any changes in hepatic and renal functions.