Unveiling the Antioxidant, Cytotoxic, and Anti-Inflammatory Activities and Chemical Compositional Information of an Invasive Plant: Lycium ferocissimum Miers

Koşar M., Şeker Karatoprak G., Atlı B., İlgün S., Köngül Şafak E., Öztinen N., ...Daha Fazla

PLANTS, cilt.13, sa.7, ss.1-17, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.3390/plants13071035
  • Dergi Adı: PLANTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1-17
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this study, the antioxidant (DPPH and ABTS radical-scavenging, ferric-reducing, iron (II)-chelating), anti-inflammatory (LPS-induced Raw 264.7 cell line), and cytotoxic activities (Du145 and A549 cell lines) of raw fruit, ripe fruit and leaves of the Lycium ferocissimum species were examined. By using high-pressure liquid chromatography, p-OH benzoic acid, caffeic acid, and rutin were detected in the ethanol and water extracts. For the most active raw fruit ethanol extract, the IC50 in terms of the DPPH-scavenging activity was 0.57 mg/mL, and the ABTS inhibition percentage was 88.73% at a 3 mg/mL concentration. The raw fruit ethanol extract exhibited significant inhibition of viability in the Du145 cell line in the concentration range of 62.5-1000 mu g/mL. Additionally, the extract effectively reduced the LPS-induced inflammation parameters (TNF-alpha, IFN-gamma, PGE 2, and NO) at a concentration of 31.25 mu g/mL. The biological activities of L. ferocissimum, which have been elucidated for the first time, have yielded promising results.