Unveiling the Antioxidant, Cytotoxic, and Anti-Inflammatory Activities and Chemical Compositional Information of an Invasive Plant: Lycium ferocissimum Miers

Koşar M., Şeker Karatoprak G., Atlı B., İlgün S., Köngül Şafak E., Öztinen N., ...More

PLANTS, vol.13, no.7, pp.1-17, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 7
  • Publication Date: 2024
  • Doi Number: 10.3390/plants13071035
  • Journal Name: PLANTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1-17
  • Erciyes University Affiliated: Yes

Abstract

In this study, the antioxidant (DPPH and ABTS radical-scavenging, ferric-reducing, iron (II)-chelating), anti-inflammatory (LPS-induced Raw 264.7 cell line), and cytotoxic activities (Du145 and A549 cell lines) of raw fruit, ripe fruit and leaves of the Lycium ferocissimum species were examined. By using high-pressure liquid chromatography, p-OH benzoic acid, caffeic acid, and rutin were detected in the ethanol and water extracts. For the most active raw fruit ethanol extract, the IC50 in terms of the DPPH-scavenging activity was 0.57 mg/mL, and the ABTS inhibition percentage was 88.73% at a 3 mg/mL concentration. The raw fruit ethanol extract exhibited significant inhibition of viability in the Du145 cell line in the concentration range of 62.5-1000 mu g/mL. Additionally, the extract effectively reduced the LPS-induced inflammation parameters (TNF-alpha, IFN-gamma, PGE 2, and NO) at a concentration of 31.25 mu g/mL. The biological activities of L. ferocissimum, which have been elucidated for the first time, have yielded promising results.