The main objective of this study was to investigate the affinity and efficiency of anion-exchange resins on natural organic matter (NOM) removal in waters with low specific UV absorbance (SUVA) and high sulfate. Two low-SUVA surface waters (Camlidere and Kesikkopru) with different sulfate concentrations were used. NOM removal batch experiments using MIEX and DOWEX 11 resins were conducted at different resin doses. NOM removals by both resins were higher in low-sulfate-content than in high-sulfate-content waters. Continuous sorption tests were then conducted using both resins. To better investigate the effect of sulfate on dissolved organic carbon (DOC) removal, sulfate spiking was employed with different influent sulfate concentrations in Camlidere (17-300 mg/L) and Kesikkopru (390-600 mg/L) water samples. The decrease in NOM removal from 60% to 20% observed with increasing influent sulfate concentration indicates that sulfate content is a more important parameter influencing DOC removal than the contents of other anions such as bicarbonate, nitrate, and bromide.