The aim of this study is to examine the relationship between tourism development and economic growth in the Mediterranean countries using the newly developed panel Granger causality tests for the 1995-2010 period. It is concluded that while there is bidirectional causal nexus between tourism development and economic growth for Portugal, unidirectional causal nexus from economic growth to tourism development is found for Spain, Italy, Tunisia, Cyprus, Croatia, Bulgaria and Greece. Therefore, the growth-led tourism hypothesis is supported in case of these seven countries. On the other hand, there is no causal relation for Malta and Egypt. The study finds evidence to support the tourism-led growth hypothesis for a group of panel in Mediterranean countries. The results of the overall study suggest that governments of Mediterranean countries should focus on economic policies to promote tourism as a potential source of economic growth.