Synthesis and Antistaphylococcal Activity of N-Substituted-1H-benzimidazole-sulphonamides

Puskullu M. O., Yildiz S., Goker H.

ARCHIV DER PHARMAZIE, vol.343, no.1, pp.31-39, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 343 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1002/ardp.200900199
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-39
  • Keywords: Anti-staphylococcal activity, 1H-Benzimidazolesulphonamide, Methicillin-resistant Staphylococcus aureus, Tautomerism
  • Erciyes University Affiliated: No

Abstract

A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (mu g/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 mu g/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 mu g/mL MIC values.