Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole

Esmaeili A., Schlatterer K., Demirhan I., Schlatterer B., Nauck M., Chandra P., ...Daha Fazla

ANTICANCER RESEARCH, cilt.26, ss.4203-4212, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2006
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4203-4212
  • Erciyes Üniversitesi Adresli: Evet

Özet

The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic affect was studied.