Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole


Esmaeili A., Schlatterer K., Demirhan I. , Schlatterer B., Nauck M., Chandra P., et al.

ANTICANCER RESEARCH, cilt.26, ss.4203-4212, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26
  • Basım Tarihi: 2006
  • Dergi Adı: ANTICANCER RESEARCH
  • Sayfa Sayısı: ss.4203-4212

Özet

The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic affect was studied.