Impact of Interleukin 28B Genotype on the Virological Responses in Chronic Hepatitis C Treatment


AYGEN B., YILDIZ O., AKHAN S., Gunal O., TAHERİ S., ZARARSIZ G., ...More

GASTROENTEROLOGY RESEARCH, vol.7, no.5-6, pp.123-130, 2014 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 5-6
  • Publication Date: 2014
  • Doi Number: 10.14740/gr629e
  • Journal Name: GASTROENTEROLOGY RESEARCH
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.123-130
  • Keywords: Chronic hepatitis C, Interleukin 28B, Polymorphism, Genetic, Pegylated interferon, GENETIC-VARIATION, SPONTANEOUS CLEARANCE, VIRUS-INFECTION, PLUS RIBAVIRIN, IL28B, ASSOCIATION, THERAPY, POLYMORPHISMS, MANAGEMENT, TURKEY
  • Erciyes University Affiliated: Yes

Abstract

Background: Interleukin (IL) 28B single nucleotide polymorphisms may play a role in the clearance of hepatitis C virus (HCV). We aimed to evaluate the treatment response of chronic HCV infection patients to pegile interferon (pegIFN) and ribavirin treatment with regard to IL28B rs12979860 C/T polymorphism.