The distribution indices of erythrocytes: which one for acute ischemic stroke?

Ekici Günay N., Günay N.

Turkish Journal Of Biochemistry-Türk Biyokimya Dergisi, vol.44, pp.1-11, 2019 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 44
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2019-0103
  • Title of Journal : Turkish Journal Of Biochemistry-Türk Biyokimya Dergisi
  • Page Numbers: pp.1-11



The erythrocytes distribution indices are reported from same histogram but they have different reference intervals and calculated by distinct measurements.


To explore whether the RDW-CV and RDW-SD values may predictive and prognostic significance in ischemic stroke patients and to clarify the relation each of these indices with stroke severity and 3-months survival.

Materials and methods

Cumulative survival rates were calculated with the Kaplan-Meier method, and life curves were compared to RDW-CV, RDW-SD quartiles. The risk factors were described with a multivariable cox proportional hazard model.


In acute ischemic stroke, RDW-CV was more specific and RDW-SD was more sensitive (92% vs. 80%) (52% vs. 48%). RDW-CV values higher than 14.7% are associated with 11-fold increase in the risk of stroke; and the level of RDW-CV does show a linear relationship with the severity of stroke. However, when we evaluated RDW-SD, higher 43.55 fL RDW-SD values was have 16-fold increase in severity of stroke and have a relatively high linear relationship with stroke severity scores to RDW-CV.


RDW-CV and RDW-SD levels have different prognostic poor outcomes for interpreting in ischemic stroke events approach and these should be used alone and comparatively with the AIS predictive and prognostic approach.

Keywords: Red blood cell distribution widthHistogramIschemic strokeSurvivalPredictive