Eritrosit dağılım indeksleri: Akut iskemik inme için hangisi?


Ekici Günay N., Günay N.

Turkish Journal Of Biochemistry-Türk Biyokimya Dergisi, cilt.44, ss.1-11, 2019 (SCI Expanded İndekslerine Giren Dergi)

  • Cilt numarası: 44
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2019-0103
  • Dergi Adı: Turkish Journal Of Biochemistry-Türk Biyokimya Dergisi
  • Sayfa Sayısı: ss.1-11

Özet

Background

The erythrocytes distribution indices are reported from same histogram but they have different reference intervals and calculated by distinct measurements.

Objectives

To explore whether the RDW-CV and RDW-SD values may predictive and prognostic significance in ischemic stroke patients and to clarify the relation each of these indices with stroke severity and 3-months survival.

Materials and methods

Cumulative survival rates were calculated with the Kaplan-Meier method, and life curves were compared to RDW-CV, RDW-SD quartiles. The risk factors were described with a multivariable cox proportional hazard model.

Results

In acute ischemic stroke, RDW-CV was more specific and RDW-SD was more sensitive (92% vs. 80%) (52% vs. 48%). RDW-CV values higher than 14.7% are associated with 11-fold increase in the risk of stroke; and the level of RDW-CV does show a linear relationship with the severity of stroke. However, when we evaluated RDW-SD, higher 43.55 fL RDW-SD values was have 16-fold increase in severity of stroke and have a relatively high linear relationship with stroke severity scores to RDW-CV.

Conclusions

RDW-CV and RDW-SD levels have different prognostic poor outcomes for interpreting in ischemic stroke events approach and these should be used alone and comparatively with the AIS predictive and prognostic approach.

Keywords: Red blood cell distribution widthHistogramIschemic strokeSurvivalPredictive