Akademik Veri Yönetim Sistemi
Erciyes Tip Dergisi, cilt.33, sa.2, ss.99-102, 2011 (Scopus)
Purpose: Determination of HCV genotypes in terms of management and treatment of chronic hepatitis C patients provides important information. In HCV genotype 1b, both lower rate of response to interferon treatment occurs and there is more risk for development of hepatocellular carcinoma. The purpose of this study was to investigate the distribution of HCV genotypes among patients from different clinics with the pre-diagnosis of chronic hepatitis C and positive for HCV RNA in blood samples. Material and Methods: Blood samples of 146 patients were included in this study. Ninety- eight patients were females (67.1%) and 48 males (32.9%). HCV genotype analyses of the samples were investigated by pyrosequencing method (Qiagen, Germany). Results: Genotype 1, genotype 4 and genotype 2 were detected in 90 (61.7%) of patients, 52 (35.6%) of patients and 4 (2.7%) of the patients respectively. In genotype 1 group, genotype 1b was detected in 77 of 90 samples and genotype 1a was detected in 5 of 90 samples 1, however subgenotyping failed in 8 patients. Conclusion: As a result, HCV genotype 1b is the most common genotype in patients with chronic hepatitis C.