Akademik Veri Yönetim Sistemi
10th International Conference on Materials Science and Nanotechnology For Next Generation (MSNG-2023) 27-29 September 2023 / TÜRKİYE , Kayseri, Türkiye, 27 - 29 Eylül 2023, ss.69-70, (Özet Bildiri)
Pharmaceutical active substances, which are micropollutants, play an important role in increasing environmental pollution. These pollutants cause negative effects on aquatic life and human health due to their permanent structure and bioaccumulation properties. These pharmaceutical active ingredients are found in very high concentrations, especially in hospital wastewater, compared to other wastewater. The fact that drug active substances in hospital wastewater reach the receiving environment without being purified in conventional wastewater treatment plants directs researchers to conduct research on the removal of these active substances with synthesized nanomaterials. In this study, the removal of Pazopanib, known as an anti-cancer drug used in the treatment of breast cancer and marketed worldwide, from hospital wastewater using the solid phase extraction method was examined. The examined wastewater samples were obtained from 4 different points determined on the sewage structures of Erciyes University Hospital. In the first stage of the study, a multifunctional nanomaterial was synthesized because it is an adsorbent with a large surface area in the solid phase extraction method and has photocatalyst performance due to other dopant species in its structure. In the second stage of the study, the performance of the synthesized nanomaterial as an adsorbent in solid phase extraction, separation, purification and enrichment of the pazopanib drug active species was examined. Measurements were carried out in UPLC at a wavelength of 270 nm. When the obtained data were examined, experimentally optimum conditions were found to be pH 8, amount of adsorbent substance 75 mg, eluent type methanol, eluent volume 2 mL, sample volume 20 mL. Following the determination of optimum conditions, pazopanib addition and recovery studies were carried out on real samples taken from 4 different pollutant sources. Recoveries were found to be between 92–108%. Until this stage of the experiments, only the solid phase extraction performance of the synthesized nanomaterial has been studied. In the future, the effects of photocatalytic performance parameters on the removal of pazopanib will be examined.