Efficacy of a Single Preoperative Dose of Pregabalin for Postoperative Pain After Septoplasty

Sagit M. , Yalcin S., POLAT H., KORKMAZ F., CETINKAYA S., Somdas M. A.

JOURNAL OF CRANIOFACIAL SURGERY, vol.24, no.2, pp.373-375, 2013 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1097/scs.0b013e31827fece5
  • Page Numbers: pp.373-375


We aimed to investigate the role of preoperative single dose of pregabalin for attenuating postoperative pain and analgesic consumption in patients undergoing septoplasty. One hundred forty-three patients with ASA physical status I who underwent elective septoplasty were included in this prospective, randomized, and controlled study. Subjects were randomized to receive pregabalin 75 mg, pregabalin 150 mg, and control group. All the medications were administered orally 1 hour before surgery. A standard septoplasty technique was used for all patients. Postoperative pain intensity was evaluated by a 0- to 100-mm horizontal visual analog scale (VAS) (0, no pain; 100, worst imaginable pain). Total analgesic consumption 1 to 24 h after operation was also recorded.