Effects of TGF-beta 1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells

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Salkın H., Gönen Z. B., Ergen E., Bahar D., Çetin M.

INTERNATIONAL JOURNAL OF STEM CELLS, cilt.12, sa.1, ss.170-182, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.15283/ijsc18051
  • Dergi Adı: INTERNATIONAL JOURNAL OF STEM CELLS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.170-182
  • Anahtar Kelimeler: Dental Pulp-derived Mesenchymal Stem Cells, TGF-beta 1, Proliferation, Apoptosis, Multilineage differentiation, Gene therapy, STEM-CELLS, TGF-BETA, TRANSFORMING GROWTH-FACTOR-BETA-1, CELLULAR SENESCENCE, DIFFERENTIATION, GROWTH, PROLIFERATION, TRIGGERS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-beta 1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA damage and senescence of human Dental Pulp-derived Mesenchymal Stromal Cells (hDPSC).