Effects of TGF-beta 1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells


Creative Commons License

Salkın H., Gönen Z. B., Ergen E., Bahar D., Çetin M.

INTERNATIONAL JOURNAL OF STEM CELLS, vol.12, no.1, pp.170-182, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.15283/ijsc18051
  • Journal Name: INTERNATIONAL JOURNAL OF STEM CELLS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.170-182
  • Keywords: Dental Pulp-derived Mesenchymal Stem Cells, TGF-beta 1, Proliferation, Apoptosis, Multilineage differentiation, Gene therapy, STEM-CELLS, TGF-BETA, TRANSFORMING GROWTH-FACTOR-BETA-1, CELLULAR SENESCENCE, DIFFERENTIATION, GROWTH, PROLIFERATION, TRIGGERS
  • Erciyes University Affiliated: Yes

Abstract

Objective: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-beta 1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA damage and senescence of human Dental Pulp-derived Mesenchymal Stromal Cells (hDPSC).