Effect of reproductive tract environment following controlled ovarian hyperstimulation treatment on embryo development and global transcriptome profile of blastocysts: implications for animal breeding and human assisted reproduction

Gad, A.; Besenfelder, U.; Rings, F.; Ghanem, N.; Salilew-Wondim, D.; Hossain, M.; Tesfaye, D.; Lonergan, P.; Becker, A.; Cinar, MEHMET; Schellander, K.; Havlicek, V.; Hoelker, M.

doi:10.1093/humrep/der110

Effect of reproductive tract environment following controlled ovarian hyperstimulation treatment on embryo development and global transcriptome profile of blastocysts: implications for animal breeding and human assisted reproduction

Atıf İçin Kopyala

Gad A., Besenfelder U., Rings F., Ghanem N., Salilew-Wondim D., Hossain M. M., ...Daha Fazla

HUMAN REPRODUCTION, cilt.26, sa.7, ss.1693-1707, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 7
Basım Tarihi: 2011
Doi Numarası: 10.1093/humrep/der110
Dergi Adı: HUMAN REPRODUCTION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1693-1707
Anahtar Kelimeler: ovulation induction, hyperstimulation, transcriptome profile, reproductive tract, bovine blastocysts, DEPENDENT PROTEIN-KINASE, IN-VITRO, PROGESTERONE CONCENTRATION, BOVINE EMBRYOS, UTERINE FLUID, SYSTEMIC PROGESTERONE, GENETIC-REGULATION, PREIMPLANTATION, OVIDUCT, STIMULATION
Erciyes Üniversitesi Adresli: Hayır

Özet

BACKGROUND: In mammals, the reproductive tract plays a crucial role in the success of early reproductive events and provides an optimal microenvironment for early embryonic development. However, changes in the reproductive tract environment associated with controlled ovarian hyperstimulation and the influence on the embryo transcriptome profile have not been investigated. Therefore, we investigated differences in the development rate and the transcriptome profile of bovine blastocysts developing in the reproductive tract of unstimulated or superovulated heifers.