Effect of reproductive tract environment following controlled ovarian hyperstimulation treatment on embryo development and global transcriptome profile of blastocysts: implications for animal breeding and human assisted reproduction

Gad A., Besenfelder U., Rings F., Ghanem N., Salilew-Wondim D., Hossain M. M. , ...Daha Fazla

HUMAN REPRODUCTION, cilt.26, sa.7, ss.1693-1707, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Konu: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1093/humrep/der110
  • Sayfa Sayıları: ss.1693-1707


BACKGROUND: In mammals, the reproductive tract plays a crucial role in the success of early reproductive events and provides an optimal microenvironment for early embryonic development. However, changes in the reproductive tract environment associated with controlled ovarian hyperstimulation and the influence on the embryo transcriptome profile have not been investigated. Therefore, we investigated differences in the development rate and the transcriptome profile of bovine blastocysts developing in the reproductive tract of unstimulated or superovulated heifers.