We report the bone scan appearance of reperfusion injury involving the muscle groups of the lower extremities in a patient after undergoing thromboembolectomy of the bilaterally femoral artery. The patient was referred to our department with a history of colon adenocarcinoma and widespread bone pain. Bone scan demonstrated extraosseous accumulation of technetium-99m methylene diphosphonate in the muscle groups of the lower extremities, predominantly in the right extremity. Pathologic examination of the gastrocnemius muscle was suggestive of reperfusion injury and atrophic changes. There was no finding of rhabdomyolysis.