Controlled ovarian hyperstimulation induced changes in the expression of circulatory miRNA in bovine follicular fluid and blood plasma


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NOFERESTI S. S. , Sohel M. M. H. , Hoelker M., SALILEW-WONDIM D., THOLEN E., LOOFT C., ...Daha Fazla

JOURNAL OF OVARIAN RESEARCH, cilt.8, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Despite its role in increasing the number of offspring during the lifetime of an individual animal, controlled ovarian hyperstimulation (COH) may have detrimental effects on oocyte development, embryo quality and endometrial receptivity. Circulating miRNAs in bio-fluids have been shown to be associated with various pathological conditions including cancers. Here we aimed to investigate the effect of COH on the level of extracellular miRNAs in bovine follicular fluid and blood plasma and elucidate their mode of circulation and potential molecular mechanisms to be affected in the reproductive tract.