Neuroprotective effects of thymoquinone against ketamine -and MK-801-induced neurotoxicity in SH-SY5Y cells: From the perspective of glutamatergic dysfunction in schizophrenia

ÜNAL G., Erdogan B.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.10, no.2, pp.178-182, 2020 (ESCI) identifier


Objective: Schizophrenia is a chronic disorder with approximately 1% prevalence and related to disrupted neurodevelopment process. It has been known that N-methyl D-Aspartate (NMDA) receptor antagonists such as ketamine and MK-801 mimic schizophrenia-like behaviors in rodents and cellular changes in cell culture. There are certain preliminary reports showing the beneficial effects of Nigella sativa L. extracts or its main active ingredient, thymoquinone, on psychiatric disorders. In our study, we aimed to investigate the neuroprotective effects of thymoquinone against ketamine - and MK-801 - induced neurotoxicites, which may be relevant to schizophrenia.