Blood pressure relationship to nitric oxide, lipid peroxidation, renal function, and renal blood flow in rats exposed to low lead levels


Dursun N. , Arifoglu C., Suer C. , Keskinol L.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.104, no.2, pp.141-149, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1385/bter:104:2:141
  • Title of Journal : BIOLOGICAL TRACE ELEMENT RESEARCH
  • Page Numbers: pp.141-149
  • Keywords: lead, blood pressure, renal blood flow, creatinine clearance, nitric oxide, L-NAME, INDUCED HYPERTENSION, SUPEROXIDE-DISMUTASE, IMPAIRMENT, SYSTEM

Abstract

The results of experiments designed to show that inhibition of nitric oxide production in rats exposed to low lead levels increases vascular resistance, decreases renal blood flow and glomerular function, and enhances oxidative stress. Forty-five adult male Sprague-Dawley rats were divided into four groups. Group A was used as controls and consisted of rats that received no treatment; group B acted as NO-inhibited controls by receiving L-NAME (N-G-nitro-L-arginine methyl ester) as the NO inhibitor; group C was injected intraperitoneally with 8 mg/kg lead acetate for 2 wk; and group D receiving lead acetate Plus L-NAME.