Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats


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Argun M. , ÜZÜM K. , Sonmez M. F. , Ozyurt A. , KARABULUT D. , SOYERSARICA Z. , et al.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, ss.234-241, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/akd.2015.6185
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayısı: ss.234-241

Özet

Objective: The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in rats with doxorubicin cardiotoxicity.