Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats


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Argun M., ÜZÜM K., Sonmez M. F., Ozyurt A., KARABULUT D., SOYERSARICA Z., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.16, no.4, pp.234-241, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.5152/akd.2015.6185
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.234-241
  • Keywords: doxorubicin, cardiotoxicity, metformin, antioxidant, echocardiography
  • Erciyes University Affiliated: Yes

Abstract

Objective: The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in rats with doxorubicin cardiotoxicity.