Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

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Argun M., ÜZÜM K., Sonmez M. F., Ozyurt A., KARABULUT D., SOYERSARICA Z., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, sa.4, ss.234-241, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/akd.2015.6185
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.234-241
  • Anahtar Kelimeler: doxorubicin, cardiotoxicity, metformin, antioxidant, echocardiography, ADRIAMYCIN-INDUCED CARDIOMYOPATHY, ADOLESCENT CANCER, OXIDATIVE STRESS, CHILDHOOD, EXPRESSION, APOPTOSIS, SURVIVORS, INJURY, INHIBITION, PROTECTS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in rats with doxorubicin cardiotoxicity.