Investigation of double carbapenem efficiency in experimental sepsis of colistin resistant Klebsiella pneumoniae
Northern Clinics Of Istanbul, cilt.8, ss.113-118, 2021 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8
- Basım Tarihi: 2021
- Doi Numarası: 10.14744/nci.2020.14238
- Dergi Adı: Northern Clinics Of Istanbul
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.113-118
- Anahtar Kelimeler: Coastal resistance, experimental sepsis, Klebsiella pneumoniae
- Erciyes Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a "last resort" antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.