Investigation of double carbapenem efficiency in experimental sepsis of colistin resistant Klebsiella pneumoniae

KOŞAR İ., DİNÇ G., EREN E., AYKEMAT Y., KILIÇ M., KILIÇ H., ...Daha Fazla

Northern Clinics Of Istanbul, cilt.8, ss.113-118, 2021 (Hakemli Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.14744/nci.2020.14238
  • Dergi Adı: Northern Clinics Of Istanbul
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.113-118
  • Anahtar Kelimeler: Coastal resistance, experimental sepsis, Klebsiella pneumoniae, IN-VITRO ACTIVITY, BLOOD-STREAM INFECTIONS, MOLECULAR EPIDEMIOLOGY, COMBINATION, MEROPENEM, TIGECYCLINE, ERTAPENEM
  • Erciyes Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a "last resort" antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.