EFFECT OF DIHIDROPYRIDINE CALCIUM ANTAGONİST NITRENDIPINE IN EXPERIMENTAL DIABETES

Gürsoy Ş., DOKUMACI A. H., Berk A., Kaymaz B., İlhan P. D. N., Aktay P. D. G.

Drug Research & Development, Antalya, Turkey, 28 - 30 November 2013, pp.96, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.96
  • Erciyes University Affiliated: Yes

Abstract

EFFECT OF  DIHIDROPYRIDINE CALCIUM ANTAGONİST NITRENDIPINE 

 IN EXPERIMENTAL DIABETES  

 

Şule GÜRSOY1, Alim Hüseyin DOKUMACI1, Ahmet BERK1, Bahadır KAYMAZ1,

Nevin İLHAN2, Göknur AKTAY1

 

1 İnönü University, Faculty of Pharmacy, Pharmacology, 44280 Malatya, Türkiye, (sulegursoy@hotmail.com)

2  Fırat University, Faculty of Medicine, Biochemistry, 23119, Elazığ, Türkiye

 

 The production of reactive oxygen species (ROS) is central to the pathogenesis of diabetes and its complications1. Dihydropyridine calcium antagonists such as nitrendipine (NIT), have been demonstrated to possess antioxidant activity and to reduce the intracellular production of  ROS besides their antihypertensive actions, independent of calcium channel modulation2. The aim of this study was to examine the  STZ induced-diabetes and its modulation on treatment with nitrendipine. The rats were divided 3 groups; Control (0.5ml cold citrate buffer 0.1M, pH 4.5, i.p.), STZ (45mg/kg, in cold citrate buffer 0.1M, pH 4.5, i.p.) and NIT (10mg/kg/day in the standard feed).  After the 7 weeks from NIT treatment, the rats were sacrificed and tissues were removed to evalute the lipid peroxidation (TBARS), GSH, TSH and NO levels.

 

 

NIT treatment significantly decreased the  STZ-induced TBARS levels in kidney and eye (p<0.05), heart (p<0.01) and brain (p<0.001). Significant ameliorates were also observed in the GSH and TSH levels in liver, kidney and heart tissues according to STZ group. Amazingly, ALT and AST levels were decreased with NIT therapy together with the fasting blood glucose level.

 

We concluded that low dose NIT treatment may protect some diabetic complications in the long term diabetes management.

 

[1]-Pazdro, R, Burgess JR. The role of vitamin E and oxidative stress in diabetes complications.  Mech.Ageing.Dev,131,276-286,2010.

 

[2]-Pizarro-Urzúa NA,Núñez-Vergara LJ. Nifedipine and nitrendipine reactivity toward singlet oxygen  Photochem. Photobiol. A: Chemistry, 175, 129-137, 2005