Increased EGFR mRNA Expression Levels in Non-Small Cell Lung Cancer

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Tasdemir S., TAHERİ S., AKALIN H., KONTAŞ O., ÖNAL Ö., ÖZKUL Y.

EURASIAN JOURNAL OF MEDICINE, cilt.51, sa.2, ss.177-185, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/eurasianjmed.2016.0237
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.177-185
  • Anahtar Kelimeler: NSCLC, EGFR, mutation, mRNA, protein, Turkey, GROWTH-FACTOR RECEPTOR, KINASE DOMAIN MUTATIONS, GENE COPY NUMBER, GEFITINIB SENSITIVITY, ACTIVATING MUTATIONS, CLINICOPATHOLOGICAL FEATURES, PROTEIN EXPRESSION, AMPLIFICATION, SURVIVAL, PREDICTORS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: In this study, we investigated the frequency of Epidermal growth factor receptor (EGFR) gene mutations, the level of EGFR mRNA and protein expressions in Turkish population for indicating substantial differences in the frequency of EGFR mutations, EGFR amplification and EGFR protein expression between populations and the effect of these parameters in response to EGFR tyrosine kinase inhibitors.