Increased EGFR mRNA Expression Levels in Non-Small Cell Lung Cancer

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Tasdemir S., TAHERİ S., AKALIN H., KONTAŞ O., ÖNAL Ö., ÖZKUL Y.

EURASIAN JOURNAL OF MEDICINE, vol.51, no.2, pp.177-185, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.5152/eurasianjmed.2016.0237
  • Journal Name: EURASIAN JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.177-185
  • Keywords: NSCLC, EGFR, mutation, mRNA, protein, Turkey, GROWTH-FACTOR RECEPTOR, KINASE DOMAIN MUTATIONS, GENE COPY NUMBER, GEFITINIB SENSITIVITY, ACTIVATING MUTATIONS, CLINICOPATHOLOGICAL FEATURES, PROTEIN EXPRESSION, AMPLIFICATION, SURVIVAL, PREDICTORS
  • Erciyes University Affiliated: Yes

Abstract

Objective: In this study, we investigated the frequency of Epidermal growth factor receptor (EGFR) gene mutations, the level of EGFR mRNA and protein expressions in Turkish population for indicating substantial differences in the frequency of EGFR mutations, EGFR amplification and EGFR protein expression between populations and the effect of these parameters in response to EGFR tyrosine kinase inhibitors.