JOURNAL OF BIOLOGICAL CHEMISTRY, cilt.289, sa.10, ss.6791-6798, 2014 (SCI-Expanded)
Background: Hyaluronan metabolism is altered in idiopathic pulmonary arterial hypertension lung tissue.
Results: This hyaluronan is of a pathological form covalently modified by heavy chains from inter--inhibitor.
Conclusion: The distribution of this matrix in regions of abnormal vascular remodeling implies a mechanistic role.
Significance: Pathological hyaluronan matrices may direct inflammatory events and vascular changes in this disease.