Modification of Hyaluronan by Heavy Chains of Inter-alpha-Inhibitor in Idiopathic Pulmonary Arterial Hypertension


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Lauer M. E. , Aytekin M., Comhair S. A. , Loftis J., Tian L., Farver C. F. , ...Daha Fazla

JOURNAL OF BIOLOGICAL CHEMISTRY, cilt.289, ss.6791-6798, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 289 Konu: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1074/jbc.m113.512491
  • Dergi Adı: JOURNAL OF BIOLOGICAL CHEMISTRY
  • Sayfa Sayıları: ss.6791-6798

Özet

Background: Hyaluronan metabolism is altered in idiopathic pulmonary arterial hypertension lung tissue. Results: This hyaluronan is of a pathological form covalently modified by heavy chains from inter--inhibitor. Conclusion: The distribution of this matrix in regions of abnormal vascular remodeling implies a mechanistic role. Significance: Pathological hyaluronan matrices may direct inflammatory events and vascular changes in this disease.

Background: Hyaluronan metabolism is altered in idiopathic pulmonary arterial hypertension lung tissue.

Results: This hyaluronan is of a pathological form covalently modified by heavy chains from inter--inhibitor.

Conclusion: The distribution of this matrix in regions of abnormal vascular remodeling implies a mechanistic role.

Significance: Pathological hyaluronan matrices may direct inflammatory events and vascular changes in this disease.