Modification of Hyaluronan by Heavy Chains of Inter-alpha-Inhibitor in Idiopathic Pulmonary Arterial Hypertension


Creative Commons License

Lauer M. E. , Aytekin M., Comhair S. A. , Loftis J., Tian L., Farver C. F. , ...More

JOURNAL OF BIOLOGICAL CHEMISTRY, vol.289, no.10, pp.6791-6798, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 289 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.1074/jbc.m113.512491
  • Title of Journal : JOURNAL OF BIOLOGICAL CHEMISTRY
  • Page Numbers: pp.6791-6798

Abstract

Background: Hyaluronan metabolism is altered in idiopathic pulmonary arterial hypertension lung tissue.

Results: This hyaluronan is of a pathological form covalently modified by heavy chains from inter--inhibitor.

Conclusion: The distribution of this matrix in regions of abnormal vascular remodeling implies a mechanistic role.

Significance: Pathological hyaluronan matrices may direct inflammatory events and vascular changes in this disease.

Background: Hyaluronan metabolism is altered in idiopathic pulmonary arterial hypertension lung tissue. Results: This hyaluronan is of a pathological form covalently modified by heavy chains from inter--inhibitor. Conclusion: The distribution of this matrix in regions of abnormal vascular remodeling implies a mechanistic role. Significance: Pathological hyaluronan matrices may direct inflammatory events and vascular changes in this disease.