The Efficacy of Long-Term Voriconazole Prophylaxis on Seven Patients with Chronic Granulomatous Disease and Review of the Literature


Kutluğ Ş., Karadağ Ş. İ. K., Gülnar Şensoy S., Birinci A., Köker M. Y., Yıldıran A.

JOURNAL OF PEDIATRIC INFECTION, vol.15, no.4, pp.205-211, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 15 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5578/ced.20219611
  • Journal Name: JOURNAL OF PEDIATRIC INFECTION
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.205-211
  • Keywords: Chronic granulomatous disease, invasive fungal disease, primary immunodeficiency disease, prophylaxis, voriconazole
  • Erciyes University Affiliated: Yes

Abstract

Objective: Chronic granulomatous disease (CGD) a primary immunodeficiency disease that affects the innate immune system, and characterized by life-threatening and/or recurrent infections caused by bacteria and fungi. Invasive fungal diseases (IFDs) are the most common causes of death among CGD patients. Itraconazole is usually used for prophylaxis in CGD patients at high risk of IFD. However, patient compliance with oral itraconazole use is low due to gastrointestinal side effects. We aim to report the efficacy of long-term voriconazole prophylaxis for IFD on our CGD patients.