The Efficacy of Long-Term Voriconazole Prophylaxis on Seven Patients with Chronic Granulomatous Disease and Review of the Literature

Kutluğ Ş., Karadağ Ş. İ. K., Gülnar Şensoy S., Birinci A., Köker M. Y., Yıldıran A.

JOURNAL OF PEDIATRIC INFECTION, cilt.15, sa.4, ss.205-211, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5578/ced.20219611
  • Dergi Adı: JOURNAL OF PEDIATRIC INFECTION
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.205-211
  • Anahtar Kelimeler: Chronic granulomatous disease, invasive fungal disease, primary immunodeficiency disease, prophylaxis, voriconazole
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Chronic granulomatous disease (CGD) a primary immunodeficiency disease that affects the innate immune system, and characterized by life-threatening and/or recurrent infections caused by bacteria and fungi. Invasive fungal diseases (IFDs) are the most common causes of death among CGD patients. Itraconazole is usually used for prophylaxis in CGD patients at high risk of IFD. However, patient compliance with oral itraconazole use is low due to gastrointestinal side effects. We aim to report the efficacy of long-term voriconazole prophylaxis for IFD on our CGD patients.