Effect of L-carnitine on oxidative damage to liver, kidney and spleen induced by phenylhydrazine in mice


OZCAN A., ATAKISI E., KARAPEHLIVAN M., ATAKISI O., Citil M.

JOURNAL OF APPLIED ANIMAL RESEARCH, cilt.32, sa.1, ss.97-100, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/09712119.2007.9706855
  • Dergi Adı: JOURNAL OF APPLIED ANIMAL RESEARCH
  • Sayfa Sayıları: ss.97-100

Özet

To investigate the ameliorative effect of L-carnitine on phenylhydrazine induced oxidative damage to liver, kidney and spleen, twenty-eight Swiss albino mice were divided into four groups and injected 0.9% NaCl (control), 40 mg/kg/day phenylhydrazine, phenylhydrazine+L-carnitine or 1000 mg/kg/day L-carnitine. Malondialdehyde (MDA) level was found to be significantly (P<0.001) lower in phenylhydrazine+L-carnitine group compared to the phenylhydrazine group in all tissues. Reduced kidney glutathione (GSH) level in phenylhydrazine given group was restored to normal by L-carnitine. However, increased uric acid level by phenylhydrazine was not decreased by L-carnitine administration. It appears that L-carnitine may prevent tissue damage and lipid peroxidation induced by phenylhydrazine.