Effect of L-carnitine on oxidative damage to liver, kidney and spleen induced by phenylhydrazine in mice
JOURNAL OF APPLIED ANIMAL RESEARCH, cilt.32, sa.1, ss.97-100, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2007
- Doi Numarası: 10.1080/09712119.2007.9706855
- Dergi Adı: JOURNAL OF APPLIED ANIMAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.97-100
- Anahtar Kelimeler: phenylhydrazine, L-carnitine, mice, reduced glutathione, malondialdehyde, uric acid
- Erciyes Üniversitesi Adresli: Hayır
Özet
To investigate the ameliorative effect of L-carnitine on phenylhydrazine induced oxidative damage to liver, kidney and spleen, twenty-eight Swiss albino mice were divided into four groups and injected 0.9% NaCl (control), 40 mg/kg/day phenylhydrazine, phenylhydrazine+L-carnitine or 1000 mg/kg/day L-carnitine. Malondialdehyde (MDA) level was found to be significantly (P<0.001) lower in phenylhydrazine+L-carnitine group compared to the phenylhydrazine group in all tissues. Reduced kidney glutathione (GSH) level in phenylhydrazine given group was restored to normal by L-carnitine. However, increased uric acid level by phenylhydrazine was not decreased by L-carnitine administration. It appears that L-carnitine may prevent tissue damage and lipid peroxidation induced by phenylhydrazine.