Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne

Akoglu G., TAN Ç., ÇAĞDAŞ AYVAZ D. N., Tezcan I.

Journal of Cosmetic Dermatology, cilt.18, sa.1, ss.395-400, 2019 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/jocd.12558
  • Dergi Adı: Journal of Cosmetic Dermatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.395-400
  • Anahtar Kelimeler: acne, IL-1β, polymorphism, scarring, TNF α
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Background: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C.05). Conclusion: TNF α-308 and IL-1β polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.