Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne

Akoglu, Gulsen; TAN, ÇAĞMAN; ÇAĞDAŞ AYVAZ, DENİZ; Tezcan, Ilhan

doi:10.1111/jocd.12558

Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne

Akoglu G., TAN Ç., ÇAĞDAŞ AYVAZ D. N., Tezcan I.

Journal of Cosmetic Dermatology, cilt.18, sa.1, ss.395-400, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 1
Basım Tarihi: 2019
Doi Numarası: 10.1111/jocd.12558
Dergi Adı: Journal of Cosmetic Dermatology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.395-400
Anahtar Kelimeler: acne, IL-1β, polymorphism, scarring, TNF α
Erciyes Üniversitesi Adresli: Hayır

Özet

Background: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C.05). Conclusion: TNF α-308 and IL-1β polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.