Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne

Akoglu G., TAN Ç., ÇAĞDAŞ AYVAZ D. N., Tezcan I.

Journal of Cosmetic Dermatology, vol.18, no.1, pp.395-400, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1111/jocd.12558
  • Journal Name: Journal of Cosmetic Dermatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.395-400
  • Keywords: acne, IL-1β, polymorphism, scarring, TNF α
  • Erciyes University Affiliated: No

Abstract

Background: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C.05). Conclusion: TNF α-308 and IL-1β polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.