Histomorphometric evaluation of the effect of doxycycline on the healing of bone defects in experimental diabetes mellitus: A pilot study

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Copy For Citation

ALKAN A., Erdem E., Gunhan O., Karasu C.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.60, no.8, pp.898-904, 2002 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 60 Issue: 8
• Publication Date: 2002
• Doi Number: 10.1053/joms.2002.33859
• Journal Name: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.898-904
• Erciyes University Affiliated: No

Abstract

Purpose: Bone healing is impaired in diabetes mellitus, particularly due to increased collagen breakdown. Recently, tetracyclines have been used to treat experimental bone defects because they have anticollagenolytic properties, and positive effects on the healing process have been obtained. The objective of this study was to develop a computer-assisted histomorphometric technique to quantitatively determine the amount of regenerating bone within experimental bone defects in a diabetic rodent model.