Silver nanoparticle/capecitabine for breast cancer cell treatment

ÖZSOY C., KARİPER İ. A., MISIR S., Ay E., Tunoglu S., Ersez M. S., ...Daha Fazla

TOXICOLOGY IN VITRO, cilt.61, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.tiv.2019.104600
  • Dergi Adı: TOXICOLOGY IN VITRO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Breast cancer (MCF-7), Capecitabine, Silver nanoparticles, Apoptosis, MEDIATED SYNTHESIS, NANOPARTICLES, CYTOTOXICITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.