Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

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Gül Siraz Ü., Doğan M., Hatipoğlu N., Muhtaroglu S., Kurtoğlu S.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.9, sa.4, ss.293-299, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/jcrpe.4532
  • Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.293-299
  • Anahtar Kelimeler: Non-alcoholic fatty liver disease, fetuin-a, type 1 diabetes mellitus, complication, FATTY LIVER-DISEASE, HEPATIC-FIBROSIS SCORES, METABOLIC SYNDROME, TURKISH CHILDREN, ASSOCIATION, ADOLESCENTS, HEPATOCYTES, PERCENTILES, PREVALENCE, OBESITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and is increased in hepatosteatosis. We aimed to investigate the reliability of fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control.