Akademik Veri Yönetim Sistemi
Electrochimica Acta, cilt.539, 2025 (SCI-Expanded, Scopus)
This study presents a novel BaTiO₃@MnO₂ nanocomposite-based electrochemical sensor for the sensitive determination of the tyrosine kinase inhibitor Nintedanib (NIN) in real-world samples. The prepared nanocomposite was characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and FE-SEM with energy-dispersive X-ray spectroscopy (EDX) techniques, and successfully applied in Nintedanib detection. The sensor demonstrated excellent analytical performance with a linear dynamic range of 0.05 – 6.2 µM, a detection limit (LOD) of 0.0042 ± 0.002 µM, and a quantification limit (LOQ) of 0.0140 ± 0.005 µM. The developed sensor's repeatability and reproducibility were validated through multiple measurement cycles and across different electrodes, yielding relative standard deviation (RSD) values of 1.66% and 1.5%, respectively. Studies on selectivity demonstrated minimal interference from common biological and pharmaceutical substances, with an RSD of less than 3%. The robustness of the proposed method was assessed by varying critical parameters such as pH, supporting electrolyte concentration, and stirring conditions, with no significant impact on NIN recovery. Real sample analysis was successfully conducted with pharmaceutical capsules and biological specimens (serum and urine), resulting in 98% and 102% recovery rates, respectively, thereby highlighting the sensor's practical applicability for NIN quantification. The BaTiO3@MnO2- modified glassy carbon electrode (GCE) sensor exhibited excellent sensitivity, selectivity, and reliability, advancing its use in pharmaceutical and clinical applications.