Impaired erythrocytes deformability in H2O2-induced oxidative stress: Protective effect of L-carnosine

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AYDOĞAN S., Yapislar H., Artis S., Aydogan B.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.39, pp.93-98, 2008 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 39
• Publication Date: 2008
• Doi Number: 10.3233/ch-2008-1072
• Journal Name: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.93-98
• Erciyes University Affiliated: Yes

Abstract

Impaired red blood cell deformability is a hemorheological perturbation induced by many kinds of diseases. An increase in free radicals causes a reduction in erythrocyte flexibility and deformability. Carnosine is a dipeptide abundant in skeletal muscle and brain of humans. One of the main function of carnosine is its antioxidant and free-radical scavenger effect. In this study our aim is to investigate the protective effect of L-carnosine on RBCs in H2O2-induced oxidative stress in vitro conditions.