Impaired erythrocytes deformability in H2O2-induced oxidative stress: Protective effect of L-carnosine

AYDOĞAN S., Yapislar H., Artis S., Aydogan B.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.39, ss.93-98, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39
  • Basım Tarihi: 2008
  • Doi Numarası: 10.3233/ch-2008-1072
  • Dergi Adı: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.93-98
  • Erciyes Üniversitesi Adresli: Evet

Özet

Impaired red blood cell deformability is a hemorheological perturbation induced by many kinds of diseases. An increase in free radicals causes a reduction in erythrocyte flexibility and deformability. Carnosine is a dipeptide abundant in skeletal muscle and brain of humans. One of the main function of carnosine is its antioxidant and free-radical scavenger effect. In this study our aim is to investigate the protective effect of L-carnosine on RBCs in H2O2-induced oxidative stress in vitro conditions.