Impaired erythrocytes deformability in H2O2-induced oxidative stress: Protective effect of L-carnosine


AYDOĞAN S. , Yapislar H. , Artis S., Aydogan B.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.39, pp.93-98, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39
  • Publication Date: 2008
  • Doi Number: 10.3233/ch-2008-1072
  • Title of Journal : CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Page Numbers: pp.93-98

Abstract

Impaired red blood cell deformability is a hemorheological perturbation induced by many kinds of diseases. An increase in free radicals causes a reduction in erythrocyte flexibility and deformability. Carnosine is a dipeptide abundant in skeletal muscle and brain of humans. One of the main function of carnosine is its antioxidant and free-radical scavenger effect. In this study our aim is to investigate the protective effect of L-carnosine on RBCs in H2O2-induced oxidative stress in vitro conditions.