CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS


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ŞEKER KARATOPRAK G. , PASAYEVA L. , KÖNGÜL ŞAFAK E. , Goger F., Tugay O., Kosar M.

FARMACIA, cilt.67, ss.1054-1059, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 67 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.31925/farmacia.2019.6.17
  • Dergi Adı: FARMACIA
  • Sayfa Sayıları: ss.1054-1059

Özet

Aerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-alpha (TNF-alpha) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 +/- 15.07 mg(GAE)/gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-alpha production (37.26 mu M and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.