Prognostic significance of Fas (CD95/APO-1) positivity in patients with primary nodal diffuse large B-cell lymphoma

Eser B., Sarı İ., Canoz Z., Altuntaş F., çakmak E., Ozturk A., ...More

AMERICAN JOURNAL OF HEMATOLOGY, vol.81, no.5, pp.307-314, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1002/ajh.20564
  • Journal Name: AMERICAN JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.307-314
  • Keywords: apoptosis, non-Hodgkin's lymphoma, Fas, prognosis and therapy
  • Erciyes University Affiliated: Yes

Abstract

Fas (CD95/APO-1) is a protein that is mainly related to apoptosis of lymphoid cells. The increment of Fas expression is associated with long-term survival in various malignancies. However, there are limited studies regarding the effect of Fas expression on the course and prognosis of non-Hodgkin's lymphoma. The aim of this study was to investigate the significance of immunohistochemical Fas expression on the prognosis of nodal diffuse large B-cell lymphoma.