The anticarcinogenic effect of propolis in human lymphocytes culture

OZKUL Y., Silici S., EROGLU E.

PHYTOMEDICINE, cilt.12, sa.10, ss.742-747, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 10
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.phymed.2004.06.015
  • Dergi Adı: PHYTOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.742-747
  • Anahtar Kelimeler: propolis, mitotic index, micronucleus, ACID PHENETHYL ESTER, ANTIBACTERIAL ACTIVITY, CHEMICAL-COMPOSITION, BRAZILIAN PROPOLIS, MICRONUCLEUS TEST, TURKISH PROPOLIS, CANCER, PERSPECTIVES, INHIBITION, ANTIFUNGAL
  • Erciyes Üniversitesi Adresli: Evet

Özet

The in vitro anticarcinogenic potential of propolis in human lymphocytes was investigated. Blood samples were obtained from ten healthy males, non-smoking volunteers, which were incubated and exposed to increasing concentrations of propolis (0.01, 0.05, 0.1, 0.2, 0.5, 0.7 and 1.0 ml). The mean micronucleus rates were 1.47 +/- 0.38-4.02 +/- 0.64. Mitotic index rates were between 19.45 +/- 2.22 and 0.28 +/- 0.33. The differences between the control and exposed cells were statistically significant (p <= 0.05). We conclude that exposure to different concentrations of propolis cannot produce a carcinogenic effect in peripheral human lymphocytes in vitro. However, increasing micronucleus (MN) rates showed that propolis could have a carcinogenic effect in high concentrations.