Protective effects of spironolactone against anthracycline-induced cardiomyopathy


Akpek M. , Ozdogru I., Sahin O. , İNANÇ M. , DOĞAN A. , YAZICI C. , ...Daha Fazla

EUROPEAN JOURNAL OF HEART FAILURE, cilt.17, ss.81-89, 2015 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/ejhf.196
  • Dergi Adı: EUROPEAN JOURNAL OF HEART FAILURE
  • Sayfa Sayıları: ss.81-89

Özet

AimsThe protective effect of beta-blockers, ACE inhibitors, and ARBs on anthracycline cardiotoxicity has already been demonstrated, but the effect of aldosterone antagonism, which inhibits the last step of the renin-angiotensin-aldosterone system (RAAS), was questioned. This study sought to investigate whether spironolactone protects the heart against anthracycline-induced cardiotoxicity.