Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis


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TOKGÖZ B. , Ucar C. , KOÇYİĞİT I. , Somdas M., ÜNAL A. , VURAL A. , ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.26, ss.4073-4078, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 12
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1093/ndt/gfr211
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Sayfa Sayıları: ss.4073-4078

Özet

Aim. Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD) treatment. Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. N-acetylcysteine (NAC) is a molecule used in the treatment and prophylaxis of many diseases related to oxidative stress. The aim of this study was to examine whether ototoxicity due to antibiotics used in the treatment of CAPD peritonitis can be prevented by NAC.