Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis


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TOKGÖZ B. , Ucar C. , KOÇYİĞİT I. , Somdas M., ÜNAL A. , VURAL A. , ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.26, no.12, pp.4073-4078, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1093/ndt/gfr211
  • Title of Journal : NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Page Numbers: pp.4073-4078

Abstract

Aim. Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD) treatment. Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. N-acetylcysteine (NAC) is a molecule used in the treatment and prophylaxis of many diseases related to oxidative stress. The aim of this study was to examine whether ototoxicity due to antibiotics used in the treatment of CAPD peritonitis can be prevented by NAC.