Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis

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TOKGÖZ B., Ucar C., KOÇYİĞİT I., Somdas M., ÜNAL A., VURAL A., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.26, sa.12, ss.4073-4078, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 12
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1093/ndt/gfr211
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4073-4078
  • Anahtar Kelimeler: amikacin, CAPD peritonitis, NAC, ototoxicity, vancomycin, TREATMENT RECOMMENDATIONS, DIALYSIS PATIENTS, CATHETER LOSS, HEARING-LOSS, GENTAMICIN, INFECTIONS, VANCOMYCIN, MORTALITY, FREQUENCY, CYSTEINE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Erciyes Üniversitesi Adresli: Evet

Özet

Aim. Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD) treatment. Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. N-acetylcysteine (NAC) is a molecule used in the treatment and prophylaxis of many diseases related to oxidative stress. The aim of this study was to examine whether ototoxicity due to antibiotics used in the treatment of CAPD peritonitis can be prevented by NAC.