Level of Serum Adiponectin in Sjogren's Syndrome

Dogan K., Urhan M. E., Yildiz S., Derin E., ŞAHİN A., DOĞAN H. O.

ERCIYES MEDICAL JOURNAL, cilt.41, sa.2, ss.186-190, 2019 (ESCI, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.14744/etd.2019.26214
  • Dergi Adı: ERCIYES MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.186-190
  • Anahtar Kelimeler: Sjogren's syndrome, adiponectin, serum
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Objective: To evaluate the serum adiponectin level and determine the association between adiponectin and various clinical and laboratory findings in patients with primary Sjogren's syndrome (pSS). Materials and Methods: A total of 50 patients and 30 healthy volunteers were enrolled in the present study. Serum adiponectin levels were detected by colorimetric enzyme-linked immunosorbent assay. The medical history of patients including complete blood count analysis; high sensitive C-reactive protein; erythrocyte sedimentation rate (ESR); complement component 3; complement component 4; low density lipoprotein cholesterol; triglyceride; immunoglobulin G (IgG), IgA, and IgM levels; and the status of Ro 60, Ro 52, Sjogren's syndrome A, Sjogren's syndrome B, and rheumatoid factor were obtained from laboratory information system. Results: Serum adiponectin levels were 2.34 (0.77-4.95) ng/mL and 1.73 (0.01-7.76) ng/mL in patients and controls, respectively (p=0.316). Positive correlation was observed between the values of serum adiponectin, ESR (p=0.013, rho=0.362), and body mass index (p=0.018, rho=0.362) in patients. Conclusion: These findings indicate that adiponectin does not play a crucial role in the immunological and clinical patterns of pSS.