154 lichen taxa are reported from 17 sampling localities in Saimbeyli, Tufanbeyli (Adana) and Develi Districts (Kayseri). Of these, 76 taxa are new for Adana and 12 taxa are new for Kayseri provinces. Besides, 23 of the reported taxa are new for the Mediterranean region of Turkey. Seven taxa namely; Acarospora badiofusca subsp. badiorubra Clauzade & Cl.Roux, Aspicilia recedens (Taylor) Arnold, Buellia pulverulenta (Anzi) Jatta, Endocarpon pulvinatum Th.Fr., Leproloma diffusum J.R.Laundon var. diffusum, Verrucaria dolosa Hepp and V. tristis Hepp are new record for Turkey. For each taxon, habitat and distributional data are provided.