Serum Levels of Angiopoietin-Related Growth Factor (AGF) Are Increased in Polycystic Ovary Syndrome

Boztosun A., Deveci K., Kilicli F., Soylemez M. S., Muhtaroglu S., MÜDERRİS I. I.

JOURNAL OF INVESTIGATIVE MEDICINE, vol.60, no.5, pp.813-817, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 5
  • Publication Date: 2012
  • Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.813-817
  • Keywords: polycystic ovary syndrome, angiopoietin-like proteins, ANGPTL6, angiopoietin-related growth factor, AGF, IMPAIRED GLUCOSE-TOLERANCE, INSULIN-RESISTANCE, METABOLIC SYNDROME, DIABETES-MELLITUS, PROTEINS, OBESITY, WOMEN, ANGIOGENESIS, PREVALENCE, PREDICTORS
  • Erciyes University Affiliated: Yes

Abstract

Background: Polycystic ovary syndrome (PCOS) is a frequent reproductive and metabolic disorder associated with insulin resistance. Recently, angiopoietins were identified in the systemic circulation and have been designated angiopoietinlike proteins (ANGPTL). More recently, it is shown that angiopoietin-related growth factor (AGF, also called ANGPTL6) directly regulate lipid, glucose, and energy metabolism independent of angiogenic effects in animal studies. The aim of this study was to determine whether there is an association between AGF and PCOS.