The relationship between primary tumor metabolic activity and lymph node and distant organ metastasis in non-small cell lung cancer Küçük Hücreli Dişi Akciǧer Kanserinde Primer Tümör Metabolik Aktivitesi ile Lenf Nodu ve Uzak Organ Metastazi Arasindaki İlişki


Yildirim F., TÜRK M., AKDEMİR Ü. Ö., Yurdakul A. S., ÖZTÜRK C.

Gazi Medical Journal, vol.29, no.3, pp.164-168, 2018 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.12996/gmj.2018.48
  • Journal Name: Gazi Medical Journal
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.164-168
  • Keywords: Metastasis, Non-small cell lung cancer, PET/CT, Primary tumor, SUVmax
  • Erciyes University Affiliated: Yes

Abstract

© Copyright 2018 by Gazi University Medical Faculty.Objective: In our study we aimed to evaluate the relationship of SUVmax of 18FDG uptake (metabolic activity) of the primary tumor on the pretreatment PET-CT to local invasion, lymph node metastasis and distant organ metastasis in patients with non-small cell lung cancer (NSCLC). Method: Hospital records of 143 patients with NSCLC who were diagnosed, followed up and treated in our thoracic oncology department between March 2009-July 2013 were retrospectively analysed. Demographic features, clinical stages, SUVmax of the primary tumor on the pretreatment PET-CT, presence of local invasion, lymph node and distant metastasis of patients were recorded. Results: Out of the 143 patients, 37 (25.8%) were at early stage (stage 1-2), 106 (74.2%) were at local-advanced stage (stage 3-4). The patients were divided into two groups based on SUVmax according to median SUVmax of 13.0; 69 patients (48.3%) had a SUVmax≥13 and 74 (51.7%) had a SUVmax<13. In the low-SUVmax group; 47 patients (63.5%) had lymph node metastasis, 33 (44.6%) has distant metastasis and 6 (8.1%) had both lymph node metastasis and distant metastasis. In the high-SUVmax group; 47 patients (68.1%) had lymph node metastasis, 27 (39.1%) has distant metastasis and 5 (7.2%) had both lymph node and distant metastasis. There were no statistically significant difference between the lymph node metastasis (p= 0.60) and distant metastasis (p=0.61) among the groups. Conclusion: In patients with NSCLC, the SUVmax at pretreatment PET-CT, which represents the metabolic activity of the tumor, can not be used in predicting the lymph node and distant metastasis.