Does clozapine really affect bone mineral density? An experimental study

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AYDIN B. K., SAFALI S., AYDIN M., Egilmez U., Cebeci H., Celik M., ...More

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol.16, no.1, 2021 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 16 Issue: 1
• Publication Date: 2021
• Doi Number: 10.1186/s13018-021-02695-w
• Journal Name: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
• Keywords: Osteoporosis, Schizophrenia, Rat, Bone mineral density, Clozapine
• Erciyes University Affiliated: Yes

Abstract

Purpose: The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model.