Does clozapine really affect bone mineral density? An experimental study


AYDIN B. K. , SAFALI S., AYDIN M., Egilmez U., Cebeci H., Celik M., ...More

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol.16, no.1, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1186/s13018-021-02695-w
  • Title of Journal : JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
  • Keywords: Osteoporosis, Schizophrenia, Rat, Bone mineral density, Clozapine, SCHIZOPHRENIA, RISK, ANTIPSYCHOTICS

Abstract

Purpose: The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model.