Does clozapine really affect bone mineral density? An experimental study

AYDIN B. K., SAFALI S., AYDIN M., Egilmez U., Cebeci H., Celik M., ...Daha Fazla

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, cilt.16, sa.1, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1186/s13018-021-02695-w
  • Dergi Adı: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: Osteoporosis, Schizophrenia, Rat, Bone mineral density, Clozapine, SCHIZOPHRENIA, RISK, ANTIPSYCHOTICS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model.