ROS induction within 4T1 breast cancer cells by CuS NPs as chemodynamic agent

Amereh M., Salmani F., Ameghani S., Ghaderzadeh R., Nosrati H., Danafar H., ...Daha Fazla

Journal of Drug Delivery Science and Technology, cilt.86, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.jddst.2023.104689
  • Dergi Adı: Journal of Drug Delivery Science and Technology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE
  • Anahtar Kelimeler: CDT, Chemodynamic therapy, CuS NPs, ROS induction
  • Erciyes Üniversitesi Adresli: Evet

Özet

Minimally invasive and highly precise cancer cell death is a goal, and nanoformulations that can respond to the unique TME hold promise. This article describes the development of a nanoparticles (NPs) for chemodynamic treatment (CDT) to combat the cancer. As a consequence, CuS NPs cores are used as Fenton-like catalysts, while Alginate (Alg) is used as a stabilizer and template for entrapping and stabilizing Cu NPs. Here, Alg coated CuS NPs (CuS@Alg NPs) was synthesized via a green and facile method. To promote biocompatibility, Alg is added to the system. The malignant cells are killed by generated toxic hydroxyl radicals (·OH) using CuS@Alg NPs as a Fenton-like process catalyst. The effectiveness of NPs was assessed by MTT assay, live/dead cells staining, and ROS generation within cancer cells. Results not only confirmed ROS generation ability of CuS@Alg NPs within cells, but also show the anticancer ability of them. By CDT, the created smart nanoscale system showed remarkable effectiveness for breast cancer suppression.