The Importance of Nucleated Red Blood Cells in Patients with Beta Thalassemia Major and Comparison of Two Automated Systems with Manual Microscopy and Flow Cytometry

KARAKÜKCÜ M., Karakukcu C., ÜNAL E., ÖZTÜRK A., cıracı Z., PATIROĞLU T., ...More

CLINICAL LABORATORY, vol.61, no.9, pp.1289-1295, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.7754/clin.lab.2015.141250
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1289-1295
  • Keywords: nucleated red blood cells, beta thalassemia major, automated hematology analyzer, flow cytometry, manual microscopy
  • Erciyes University Affiliated: Yes

Abstract

Background: Nucleated red blood cells (NRBC) can be used as a marker of erythropoietic stress and help optimize transfusion therapy in patients with beta thalassemia major. The aim of this study was to determine this correlation; and compare two automated systems (Sysmex XE-2100, and Advia 2120i) with manual microscopy and flow cytometry (FCM).