Pharmacokinetic of sulfaclozine in broiler chickens


Şentepe İ., ERASLAN G.

FOOD AND CHEMICAL TOXICOLOGY, cilt.48, ss.448-451, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 48 Konu: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.fct.2009.10.044
  • Dergi Adı: FOOD AND CHEMICAL TOXICOLOGY
  • Sayfa Sayıları: ss.448-451

Özet

In this study, 30-day-old, 14 male broiler chickens were used. Two groups, each comprising 7 animals, were established. While each animal included in the first group was administered sulfaclozine at a dose of 60 mg/kg bw by intravenous route (IV), group 2 was administered sulfaclozine at the same dose but by intracrop route (IC). In group 1, serum sulfaclozine concentrations at 0.083, 0.50, 2, 6, 24 and 72 h were determined to be 99.62 +/- 3.31, 83.50 +/- 4.22, 72.68 +/- 5.02, 58.43 +/- 5.39, 38.66 +/- 4.04 and 13.14 +/- 1.64 mu g/ml, respectively, via HPLC. In group 2, serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72 h were determined as 4.33 +/- 0.45, 7.95 +/- 0.72, 16.46 +/- 2.68, 22.88 +/- 3.00, 16.03 +/- 3.53 and 5.74 +/- 0.98 mu g/ml, respectively. Statistical analyses revealed that, of all the parameters studied, only A(1)*, A(2)*, alpha, beta, t(1/2 alpha), t(1/2 beta), MRT, Vd(area), k(12), k(21), AUC(0 -> 72) and AUC(0 ->infinity) differed significantly between the groups (p < 0.05). Compared to intravenous administration, significant increase in t(1/2 alpha), t(1/2 beta), MRT and Vd(area), and significant decrease in A(1)*, A(2)*, alpha, beta, k(12), k(21), AUC(0 -> 72) and AUC(0-infinity) were observed in the group, which was administered sulfadozine by intracrop route. (C) 2009 Elsevier Ltd. All rights reserved.