The effect of different doses of flumazenil on acetaminophen toxicity in rats

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Bozoğluer E., MADENOĞLU H., AKSU R., BİÇER C., YAZICI C., BOYACI A.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.113, no.9, pp.525-528, 2012 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 113 Issue: 9
• Publication Date: 2012
• Doi Number: 10.4149/bll_2012_118
• Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.525-528
• Keywords: flumazenil, acetaminophen, hepatotoxicity
• Open Archive Collection: AVESIS Open Access Collection
• Erciyes University Affiliated: Yes

Abstract

Background: Acetaminophen is an analgesic drug that is used safely in therapeutic doses. At high doses, it causes hepatotoxicity, resulting in hepatic necrosis. Some medications and methods are available for treatment of acetaminophen overdose. However, results are inconsistent, and sufficient outcomes cannot always be obtained.