Synthesis and potent cytotoxicity of some novel imidazopyridine derivatives against MCF-7 human breast adenocarcinoma cell line


PÜSKÜLLÜ M. O. , Karaaslan C., Bakar F., Goker H.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, cilt.51, ss.723-733, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 51 Konu: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10593-015-1765-7
  • Dergi Adı: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Sayfa Sayıları: ss.723-733

Özet

A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 mu M, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.