Synthesis and potent cytotoxicity of some novel imidazopyridine derivatives against MCF-7 human breast adenocarcinoma cell line
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, cilt.51, sa.8, ss.723-733, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 8
- Basım Tarihi: 2015
- Doi Numarası: 10.1007/s10593-015-1765-7
- Dergi Adı: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.723-733
- Anahtar Kelimeler: carboxamidine, 3H-imidazo[4,5-b]pyridine, 3H-imidazo[4,5-c]pyridine, cytotoxicity, MCF-7 cell line, steric hindrance
- Erciyes Üniversitesi Adresli: Evet
Özet
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 mu M, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.